Qiao-Hong Chen, Ph.D.

Associate Professor
Office Location: Science Building Room 346 
Office Phone: 559.278.2394 
E-mail: qchen@csufresno.edu
Website: Chen Research Group

 

Dr. Qiao-Hong Chen received her PhD degree in Medicinal Chemistry from Sichuan University, China. Appointed as a Lecturer in 2001, She was promoted to the position of Full Professor in 2003 at Sichuan University. She was a Postdoctoral Fellow for three years at the University of Alberta in Canada and a Senior Research Fellow for six years at Virginia Tech. She joined Fresno State in 2012. Her research interests focus on natural products-based anticancer agents. She has published 135 peer-reviewed scientific publications. as well as 5 book chapters.

 

Chen Research Group 2017-1

 

Areas of Specialty

Cancer is the second leading cause of death after cardiovascular disease in the United States. One out of four deaths in US are cancer related which is ca. 1500 people a day, and approximately 560,000 people a year. Drug resistance has been recognized as a major contributor to chemotherapy failure. Multidrug resistance to a range of chemotherapeutic drug ultimately leads to treatment failure in over 90% of patients with metastatic cancer. Current ongoing research projects in Dr. Chen’s group are focused on: 1).
Development of macrolide-based microtubule stabilizing agents for the treatment of multi-drug resistant cancer; and 2). Development of improved analogues of dietary natural products for the treatment of advanced metastatic hormone-refractory prostate cancer
.

 

Recent Publications (For a complete list of Publications)
  • 135. "5- or/and 20-O-Alkyl-2,3-dehydrosilybins: Synthesis and biological profiles on prostate cancer cell models", Bao Vue, Xiaojie Zhang, Timmy Lee, Nandini Nair, Sheng Zhang, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiao-Hong Chen*, Bioorganic & Medicinal Chemistry25(17): 4845-4854 (2017).

  • 134. "3-O-Substituted-3',4',5'-trimethoxyflavonols: synthesis and cell-based evaluation as anti-prostate cancer agents", Xiang Li, Maizie Lee, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, Qiao-Hong Chen*, Bioorganic & Medicinal Chemistry, 25(17): 4768-4777 (2017).

  • 133. "Immune modulation of Asian folk herbal medicines and related chemical components for cancer management", Manee Patanapongpibul and Qiao-Hong Chen*, Current Medicinal Chemistry, DOI: 10.2174/0929867324666170705112644 (2017).

  • 132. "Asymmetric 1,5-diarylpenta-1,4-dien-3-ones: antiproliferative activity in prostate epithelial cell models and pharmacokinetic studies", Xiaojie Zhang, Shanchun Guo, Chengsheng Chen, German Ruiz Perez, Changde Zhang, Manee Patanapongpibul, Nithya Subrahmanyam, Rubing Wang, Joshua Keith, Guanglin Chen, Yan Dong, Qiang Zhang, Qiu Zhong, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, European Journal of Medicinal Chemistry, 137: 263-279 (2017).

  • 131. "Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models", Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen, Cristian Sarabia, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, European Journal of Medicinal Chemistry, 133 : 208-226 (2017).

  • 130. "The Potential of Flavonolignans in Prostate Cancer Management", Bao Vue and Qiao-Hong Chen*,  Current Medicinal Chemistry, 23(34): 3925-3950  (2016).

  • 129. "Design, Synthesis, and Biological Evaluation of 1,9-Diheteroarylnona-1,3,6,8-tetraen-5-ones as a New Class of Anti-Prostate Cancer Agents", Xiaojie Zhang, Rubing Wang, German R Perez, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, Bioorganic & Medicinal Chemistry, 24(19): 4692-4700 (2016).

  • 128. "A new class of flavonol-based anti-prostate cancer agents: design, synthesis, and evaluation in cell models", Xiang Li, Guanglin Chen, Xiaojie Zhang, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, Bioorganic & Medicinal Chemistry Letters, 26(17): 4241-4245 (2016).

  • 127. "Bivalent Carbamates as Novel Control Agents of the Malaria Mosquito, Anopheles gambiae"James M. Mutunga, Qiao-Hong Chen, Dawn M Wong, Henrique Polo, Jianyong Li, Maxim M. Totrov, Aaron D Gross, Paul R. Carlier, Jeffrey R. Bloomquist, CHIMIA International Journal for Chemistry, 70(10): 704-708 (2016).

  • 126. "3-O-Alkyl-2,3-Dehydrosilibinins: Two Synthetic Approaches and in vitro Effects toward Prostate Cancer Cells", Sheng Zhang, Bao Vue, Michael Huang, Xiaojie Zhang, Timmy Lee, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, Bioorganic & Medicinal Chemistry Letters, 26(14): 3226-3231 (2016).

  • 125. "Aerobic Decomposition of Trialkylquercetins: Structure Characterization and Antiproliferative Effect", Sami M.R.Al-Jabban, Xiaojie Zhang, Guanglin Chen, Liva Harinantenaina Rakotondraibe, and Qiao-Hong Chen*, Natural Product Communications, 11: 465-468 (2016).

  • 124. "Synthesis and evaluation of 1,7-diheteroarylhepta-1,4,6-trien-3-ones as curcumin-based anti-cancer agents", Rubing Wang, Xiaojie Zhang, Chengsheng Chen, Guanglin Chen, Qiu Zhong, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, European Journal of Medicinal Chemistry, 110: 164-180 (2016).                      

  • 123. "Flavonoids with therapeutic potential in prostate cancer", Bao Vue, Sheng Zhang,  and Qiao-Hong Chen*, Anti-Cancer Agents in Medicinal Chemistry, 16(10): 1205-1229 (2016).

  • 122. "Silibinin Derivatives as Anti-Prostate Cancer Agents: Synthesis and Cell-Based Evaluations", Bao Vue, Sheng Zhang, Xiaojie Zhang, Konstantinos Parisis, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, European Journal of Medicinal Chemistry, 109: 36-46 (2016).

  • 121. "Epoxide Opening of a 7,17-Seco-7,8-Epoxy-C19-Diterpenoid Alkaloid", Hong Ji, Feng-Peng Wang* and Qiao-Hong Chen*, Natural Product Communications, 10: 2071-2074 (2015).

  • 120. "Synergistic Effects of Dietary Natural Products as Anti-Prostate Cancer Agents", Bao Vue, Sheng Zhang and Qiao-Hong Chen*, Natural Product Communications, 10: 2179-2188 (2015).

  • 119. "Further Studies on Structure-Cardiac Activity Relationships of Diterpenoid Alkaloids", Zhong-Tang Zhang, Xi-Xian Jian, Jia-Yu Ding, Hong-Ying Deng, Ruo-Bing Chao*, Qiao-Hong Chen*, Dong-Lin Chen and Feng-Peng Wang*, Natural Product Communications, 10: 2075-2084 (2015).

  • 118. "Synthesis and Anti-Proliferative Effects of Quercetin Derivatives", Sami M.R. Al-Jabban, Xiaojie Zhang, Guanglin Chen, Ermias Addo Mekuria, Liva Harinantenaina Rakotondraibe, and Qiao-Hong Chen*, Natural Product Communications, 10: 2113-2118 (2015).

  • 117. "A new class of hybrid anticancer agents inspired by the synergistic effects of curcumin and genistein: design, synthesis, and anti-proliferative evaluation", Qiao-Hong Chen*, Kevin Yu, Xiaojie Zhang, Guanglin Chen, Andrew Hoover, Francisco Leon, Rubing Wang, Nithya Subrahmanyam, Ermias A Mekuria, Liva H Rakotondraibe, Bioorganic & Medicinal Chemistry Letters, 25(20): 4553-4556 (2015).

  • 116. "Effects of curcumin-based compounds on proliferation and cell death in cervical cancer cells", Xiaojie Zhang, Rubing Wang, Guanglin Chen, Laurent Dejean*, and Qiao-Hong Chen*, Anticancer Research, 35(10): 5293-5298 (2015).

  • 115. "Structure-Activity relationship and pharmacokinetic studies of 1,5-diheteroarylpenta-1,4-dien-3-ones: a class of promising curcumin-based anti-cancer agents", Rubing Wang, Chengsheng Chen, Xiaojie Zhang, Changde Zhang, Qiu Zhong, Guanglin Chen, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, Journal of Medicinal Chemistry, 58 (11), 4713–4726 (2015).

  • 114. Design, Synthesis, and Evaluation of Genistein Analogues as Anti-cancer Agents", Pahoua Xiong, Rubing Wang, Xiaojie Zhang, Eduardo Dela Torre, Francisco Leon, Qiang Zhang, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, Anti-Cancer Agents in Medicinal Chemistry, 15(9): 1197-1203 (2015)

  • 113. "Curcumin-Based Anti-Prostate Cancer Agents", Qiao-Hong Chen*, Anti-Cancer Agents in Medicinal Chemistry, 2: 138-156 (2015).

  • 112. "Stemona Alkaloids: Biosynthesis, Classification, and Biogenetic Relationships", Feng-Peng Wang* and Qiao-Hong Chen*, Natural Product Communications, 9: 1809-1822 (2014).

  • 111. "Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant", Kevin B Temeyer*, Fan Tong, Maxim M Totrov, Alexander P Tuckow, Qiao-Hong Chen, Paul R Carlier, Adalberto A Pérez de León, Jeffrey R Bloomquist, Parasites & Vectors, 7: 577 (2014).

  • 110. "Zampanolide and Dactylolide: Cytotoxic Tubulin-Assembly Agents and Promising Anticancer Leads", Qiao-Hong Chen* and David G. I. Kingston*, Natural Product Reports, 31: 1202-1226 (2014).

  • 109. "Ring A Conformation of Aconine and Pseudaconine in CDCl3", Hong-Ying Deng, Qiao-Hong Chen*, and Feng-Peng Wang*, Natural Product Communications, 9: 785-786 (2014).

  • 108. "Total Synthesis of Fuzinoside", Ping He, Xiao-Huan Li, Qiao-Hong Chen*, Jin-Song Yang, Feng-Peng Wang*, Tetrahedron, 70: 4022-4030 (2014).

  • 107. "New C20-Diterpenoid Alkaloids from Delphinium laxicymosum var pilostachyum", Dong-Lin Chen, Ping Tang, Qiao-Hong Chen*, and Feng-Peng Wang*, Natural Product Communications, 9(5): 623-625 (2014).  

  • 106. "Further revisions on the diterpenoid alkaloids reported in a JNP paper (2012, 75, 1145-1159)", Feng-Peng Wang, Dong-Lin Chen, Hong-Ying Deng, Qiao-Hong Chen, Xiao-Yu Liu, and Xi-Xian Jian, Tetrahedron, 70: 2582-2590 (2014).                     

  • 105. "Design, synthesis, and evaluation of novel heteroaromatic analogs of curcumin as anti-cancer agents", Nawras Samaan, Qiu Zhong, Jayjoel Fermandez, Guanglin Chen, Ali M Hussain, Shilong Zheng, Guangdi Wang, and Qiao-Hong Chen*, European Journal of Medicinal Chemistry75: 123-131 (2014).

 
Recent US Patent
  • ''Therapeutic Uses of Curcumin Analogs for Treatment of Prostate Cancer", Qiao-Hong Chen, United States Patent (2016), pp36, US 9,499,529 B2.