Mihai Gherase

Title: Assistant Professor of Physics
Office: S2 311A
Phone: (559) 278-1766
Fax: (559) 278-7741 
Email: mgherase@csufresno.edu 

Dr. Gherase


Ph.D., Carleton University

Areas of Expertise and Interest

I am interested in medical and biological applications of x-ray fluorescence (XRF). XRF is a non-invasive analytical method capable of detecting chemical elements in bulk or trace concentrations (parts per million level). Following x-ray irradiation in vivo measurements of certain elements in the human body are possible with minimal radiation dose. For the past three decades the most important medical XRF application was the in vivo measurement of lead (Pb) in the tibia bone. XRF investigations of the distribution, accumulation mechanisms, and metabolic role of other elements such as iron (Fe), zinc (Zn), arsenic (As), selenium (Se), or strontium (Sr) in healthy and pathological human tissues were also pursued by various research groups. I am particularly interested in the research and development of novel in vitro and in vivo XRF measurement techniques using modern x-ray optics instrumentation and techniques. The microbeam XRF laboratory I built features an integrated x-ray tube and polycapillary x- ray lens capable of producing an x-ray beam with a focal spot of 15 μm. This XRF system is suitable for in vitro XRF microscopy studies and the research of novel medical applications in this field.

Selected Publications

1. "X-ray fluorescence measurements of arsenic micro-distribution in human nail clippings using synchrotron radiation," M.R. Gherase, E.D. Desouza, M.J. Farquharson, F.E. McNeill, C.-Y. Kim, D.E.B. Fleming, Physiological Measurement, 34(9):1163-1177 (2013)

2. "Calculation of depth-dependent elemental concentration with x-ray fluorescence using a layered calibration method," M.R. Gherase and D.E.B. Fleming, Nuclear Instruments and Methods in Physics Research Section B 269(10):1150-1156 (2011)

CV of Dr. Gherase [PDF, 200KB]

Program Page